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  • Integrative Therapeutics, Formula: 11956 - Gluten Manager 60 Capsules
  • Ingredients Label for Integrative Therapeutics Gluten Manager 60 Capsules

Gluten Manager 60 Capsules

Price:
$50.00
SKU:
11956|Integrative Therapeutics
Quantity:


Product Description



Gluten Manager™ - Digestive Enzymes

Avoiding dietary gluten can be a challenge. In a study of individuals with very high sensitivity to gluten that were following a gluten free diet, 66% suspected unintended exposure.7 Gluten can cause immunological and opioid-like effects on the nervous system of sensitive individuals. As gluten is a protein, it is typically broken down into small amino acids. However, gluten is comprised of gliadin which is difficult to digest due to the long proline peptides.

Gluten Manager has dual mechanism-of-action digestive enzymes that hydrolyzes gluten at both the middle and end of the gluten molecule through the use of prolyl-endopeptidase (Tolerase® G) and dipeptidyl-peptidase IV enzyme activity (DPP-IV)†. The use of both digestive enzymes degrades the proline peptide into smaller chains that can be more completely digested.

  • Features microbial enzymes that are stable in acidic environments
  • Helps support the breakdown of gluten
  • Smaller peptide chains for easier digestion
Theoretical mechanism of action using Tolerase G & DPP-IV†

Tolerase® G is a trademark of DSM.

  1. Salden BN, Monserrat V, Troost FJ, et al. Randomised clinical study: Aspergillus niger-derived enzyme digests gluten in the stomach of healthy volunteers. Aliment Pharmacol Ther. 2015 Aug;42(3):273-85.
  2. Mitea C, Havenaar R, Drijfhout JW, et al. Efficient degradation of gluten by a prolyl endoprotease in a gastrointestinal model: implications for coeliac disease. Gut. 2008 Jan;57(1):25-32.
  3. Stepniak D, Spaenij-Dekking L, Mitea C, et al. Highly efficient gluten degradation with a newly identified prolyl endoprotease: implications for celiac disease. Am J Physiol Gastrointest Liver Physiol. 2006 Oct;291(4):G621-9.
  4. Ehren J, MorĂłn B, Martin E, et al. A food-grade enzyme preparation with modest gluten detoxification properties. PLoS One. 2009 Jul 21;4(7):e6313.
  5. Montserrat V, Bruins MJ, Edens L, Koning F. Influence of dietary components on Aspergillus niger prolyl endoprotease mediated gluten degradation. Food Chem. 2015 May 1;174:440-5.
  6. Tack GJ, van de Water JM, Bruins MJ, et al. Consumption of gluten with gluten-degrading enzyme by celiac patients: a pilot-study. World J Gastroenterol. 2013 Sep 21;19(35):5837-47.
  7. J. A. Silvester, L. A. Graff, L. Rigaux, J. R. Walker, D. R. Duerksen. Alimentary Pharmacol Ther. 2016 Sept;44(6):612-619.


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Integrative Therapeutics' logo, text, trademarks, graphics, and photo images are the property of Schwabe North America, Inc. and are used with permission. Copyright © 2018

*FDA Disclaimer: The information about this product and statements made are provided by the manufacturer, except customer reviews which are not evaluated. See www.integrativepro.com for information about the relationship between this product and any claims made. Results may vary from person to person based on body size and other factors, and the effectiveness is not guaranteed for you. Always seek the advice of your healthcare professional about taking dietary, nutritional, herbal or homeopathic supplements.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Ingredients

Recommended Use

Take 1 or 2 capsules at the beginning of each meal or as recommended by your healthcare professional.
Servings Per Container: 30
Serving Size: 2 Capsules


Ingredients

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*FDA Required Statement: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.